In patients with advanced chronic toxic kidney disease and poorly controlled hypertension, chlorthalidone therapy improved hypertension control at 12 weeks as compared with placebo.

Reference: Agarwal R, Sinha AD, Cramer AE, Balmes-Fenwick M, et al. Chlorthalidone for hypertension in advanced chronic kidney disease. November 5, 2021. DOI: 10.1056/NEJMoa2110730.